"If you look at the viruses that are the biggest threats of modern times, most of them were unknown through human history: HIV, SARS, Ebola (see A spotter's guide to human viruses). You don't know where the next one is coming from. How do you develop therapeutics for the unknown and unknowable, given that you won't have time to develop a vaccine for a new agent after it appears?" he asks.

Goldblatt and a few other researchers think they have the answer. They are working on an entirely new class of antiviral drugs that should do something seemingly impossible: work against a wide range of existing viruses and also be effective against viruses that have not even evolved yet. What's more, it should be extremely difficult for any virus to become resistant to these drugs.

...

Back in the late 1990s, when Goldblatt was at DARPA, he began to wonder whether there was another strategy, one that exploits the key weakness of all viruses: their utter dependence on their hosts. By themselves, viruses are more helpless than newborn babies. They can replicate only by tricking their host cells into making more copies of them, a process that can involve hundreds of host proteins.

What if, Goldblatt wondered, some host proteins are essential for viral replication but not for the survival of the host? If so, disabling these proteins should block viral replication without killing healthy cells.

After moving to Functional Genetics, Goldblatt began putting his idea to the test. He and his colleagues disabled one gene at a time in human cells before exposing them to viruses such as flu. This fishing expedition worked beautifully: they identified more than 100 different human proteins that flu viruses need to replicate but which cells can survive without. Only four were previously known to be involved in viral replication.

One especially promising target is TSG101, a protein involved in the transport of materials within cells that many viruses co-opt to break out of cells. Functional Genetics has developed a small-molecule drug that appears to block the interaction between viruses and TSG101. Dubbed FGI-104, the drug inhibits a wide range of viruses in cell culture, including hepatitis C and HIV, and has also been shown to protect mice against Ebola (American Journal of Translational Research, vol 1, p 87).

As an ecologist, I'm worried about the immutable law of unintended consequences here.

As rockreaver I'm myself. As codefrog 4 people had the ability to sign in as him and they did. I've tried to get codefrog unbanned because I think that a person should be able to say "I messed up. Sorry about that." and start over.

You know... my first time here didn't go so well. I got really frustrated.

This time around I'm actually not getting stupid and agitated.

So if people can let someone start over then I'd like that. If not then well... I don't know.

I like to climb. The people here are great people and I messed up. I want to make a lot of excuses and say this or that but that would be kind of lame wouldn't it.

As rockreaver I'm myself. As codefrog 4 people had the ability to sign in as him and they did. I've tried to get codefrog unbanned because I think that a person should be able to say "I messed up. Sorry about that." and start over.

A few people here have known all along who rockreaver was and it hasn't really bothered them. I debated loading that picture but then I thought about more and realized that if you have to live a lie to be accepted by people then it ain't worth it.

Codefrog is still banned. I'm the only person who is/was rockreaver and I'm not giving that sign-in to anyone.

Codefrog was a guy from france, a guy from India and 2 guys from Australia. Rockreaver is just me.

I just want to climb, learn, be humble and not have to duck or hide my face.

So is that okay?

{EDIT} Your comments are a bit depressing though. I've lost 30 pounds between photos and you didn't notice. I'm not in the Navy. I'm not a SEAL. I'm not any of that military stuff either. I have some friends who are and that's about it. When I gave up the profile information the 4 guys decided to be 4 faces and it rolled from there. BLONDGECKO stopped it all and I think I took a bit of time off here. Now I'm back. {/EDIT}

I feel like I'm walking into dickheads anonymous:

"I'm codefrog and I'm a dickhead."

There I've said it. I'm just a normal guy now. Well mostly normal. I climb and I guess some people don't think that's normal.

Thanks for the "welcome".

A seriously stupid profile I had. It got banned. I've been rockreaver a long time.

I thought just by changing my profile pic that nobody would remember. Somebody did. So I'm back into obscurity.

I'm not a troll though. I'm just a normal guy that had a few days of bad judgment in which he gave his user/pass here to friends. They had too much fun.

Anyway, move along folks nothing to see here. I shouldn't have touched my profile picture.

Read GMBURNS conversation with me.

Who cares anyway. It wasn't me. I guess I outed them. They are gone. Not even climbers. Codefrog is gone and I guess that's fine too.

Rockreaver is here but you can read every post I've made here. I'm not the 4 cheesheads that were codefrog.

Someone got outed but not sure who...

Does it matter? It's the internet right. Out on rocks I'm safe. I'm an okay climber but I'm safe. I'm a taxpaying father, husband, etc... I own a car but only drive it to climb. The 4 guys are the odd ones. 2 of them like vegemite.

are you serious?

you just outed yourself

Ah, but which one?

or three - why assume it's down to one? maybe the 4th guy got knockedvoted off?

what you don't remember this train wreck..
http://www.rockclimbing.com/..._reply;so=ASC;mh=25;

i still think it's total bull shit that 3 other people used the account, especially the "non-climbers, who would NOT be interested in discussing climbing.........see original codefrog thread

Okay so let's just figure this out. What do you want? Me to leave? Fine. If that's going to make you sleep better then say it.

The rest of this is temporary insanity. Look at my posting here as rockreaver. What part of it is any different than what others do here?

You guys want some elitist hang out where you can gang up on people and act like demi-gods?

Can people not apologize?

I don't really care. I changed a profile picture to a new picture of me weighing 30 pounds less and now you are acting like I'm Ted Bundy or something.

What do you really want? What's the outcome you are after? If this is going to make life better for you then out with it.

Wow. I was hoping that after 150 posts as a normal human being I could just be myself.

What do you really want? If you want me to leave then just say it I'll go but the drama is...

Anyway...

macherry, sometimes people sit back and think about something that happened. Sometimes they think, "I should make it right." I'm sorry you think that's BS.

So now what? I can quit? Give the login to Dingus and 4 other people... What do you people want?

Okay so let's just figure this out. What do you want? Me to leave? Fine. If that's going to make you sleep better then say it.

The rest of this is temporary insanity. Look at my posting here as rockreaver. What part of it is any different than what others do here?

You guys want some elitist hang out where you can gang up on people and act like demi-gods?

Can people not apologize?

I don't really care. I changed a profile picture to a new picture of me weighing 30 pounds less and now you are acting like I'm Ted Bundy or something.

What do you really want? What's the outcome you are after? If this is going to make life better for you then out with it.

Wow. I was hoping that after 150 posts as a normal human being I could just be myself.

What do you really want? If you want me to leave then just say it I'll go but the drama is...

Anyway...

macherry, sometimes people sit back and think about something that happened. Sometimes they think, "I should make it right." I'm sorry you think that's BS.

So now what? I can quit? Give the login to Dingus and 4 other people... What do you people want?

I haven't read anything.

I just feel like an idiot for all of it. Totally backfired on me as it turned out to be a site I enjoy. So yeah ironic.

Nope that's true. I swear on all things holy that's true. 4 guys I write software and have known for 9 years. They are beer drinking trolls and vikings and I swear to GAWED they collaborated on every post. I never in my life thought I'd be back here but this is a great place and my kids are into climbing a lot.

Those 4 vikings are devious and they plotted to be me and I'm not shitting you at all. I swear. They know me well. I'm extremely verbose and I say too damned much. They made sure to be the same. I swear.

No it was meant to be a "go have fun" type of thing. These are 4 guys I know as well as I know anyone. I'm self-employed and I know my stuff way well.

I was a senior engineer for Micron Technology and wrote their backlog management system for memory modules and wafers. I wrote the Wildlife Management System for Idaho Fish & Game. I wrote the archived license lookup system for Idaho Fish & Game.

When it comes to source code I'm really good. I just got annoyed and on an impulse gave the account away. Then it got worse and worse. I followed it for a bit and then just kind of got really ashamed. So I tried to come back as wayfarer but somebody spotted that in no time flat and I was on the defensive so I gave up.

I registered rockreaver but I didn't post for a very long time (or I think that's right... that was the plan). Then I just tried to be very vanilla. I had real questions I wanted help with and I knew there were good people here. Some of them whom I won't mention have been cool since day one and each time I morphed I told them that I was agent X or Y or Z and they were like "okay".

I have been paid very well to catch hackers. I've programmed CISCO IOS for firewalls. I've done it all and I'm pretty good. I'm pretty burned out on life though keeping a kid alive and the debt has me really fried. All I want to do is climb. That means I hang out here and I read, and read and read and read and read.

Then I add a picture and my whole world goes right to hell. Oh well. You get what you earn and I earned what I'm getting.

No it was meant to be a "go have fun" type of thing. These are 4 guys I know as well as I know anyone. I'm self-employed and I know my stuff way well.

I was a senior engineer for Micron Technology and wrote their backlog management system for memory modules and wafers. I wrote the Wildlife Management System for Idaho Fish & Game. I wrote the archived license lookup system for Idaho Fish & Game.

When it comes to source code I'm really good. I just got annoyed and on an impulse gave the account away. Then it got worse and worse. I followed it for a bit and then just kind of got really ashamed. So I tried to come back as wayfarer but somebody spotted that in no time flat and I was on the defensive so I gave up.

I registered rockreaver but I didn't post for a very long time (or I think that's right... that was the plan). Then I just tried to be very vanilla. I had real questions I wanted help with and I knew there were good people here. Some of them whom I won't mention have been cool since day one and each time I morphed I told them that I was agent X or Y or Z and they were like "okay".

I have been paid very well to catch hackers. I've programmed CISCO IOS for firewalls. I've done it all and I'm pretty good. I'm pretty burned out on life though keeping a kid alive and the debt has me really fried. All I want to do is climb. That means I hang out here and I read, and read and read and read and read.

Then I add a picture and my whole world goes right to hell. Oh well. You get what you earn and I earned what I'm getting.

so you set up a troll account and invite others to mess around with it? nice asshat move. its hard to keep your story straight, i thought they broke into the account.

so we should respect you and your posts?

funny how this sounds exactly like the 'i'm an ex-seal, fuck all you guys you don't understand me' bit.

also funny how quickly cf/wf/rr goes defensively crazytits, when the only thing that happened was that gmburns- good spot, btw- was like "huh, you look just like codefrog." the response could have been "that's weird, who is that guy?" but instead it was "my whole world goes right to hell."

You know... my first time here didn't go so well. I got really frustrated.

This time around I'm actually not getting stupid and agitated.

So if people can let someone start over then I'd like that. If not then well... I don't know.

I like to climb. The people here are great people and I messed up. I want to make a lot of excuses and say this or that but that would be kind of lame wouldn't it.

As rockreaver I'm myself. As codefrog 4 people had the ability to sign in as him and they did. I've tried to get codefrog unbanned because I think that a person should be able to say "I messed up. Sorry about that." and start over.

A few people here have known all along who rockreaver was and it hasn't really bothered them. I debated loading that picture but then I thought about more and realized that if you have to live a lie to be accepted by people then it ain't worth it.

Codefrog is still banned. I'm the only person who is/was rockreaver and I'm not giving that sign-in to anyone.

Codefrog was a guy from france, a guy from India and 2 guys from Australia. Rockreaver is just me.

I just want to climb, learn, be humble and not have to duck or hide my face.

So is that okay?

{EDIT} Your comments are a bit depressing though. I've lost 30 pounds between photos and you didn't notice. I'm not in the Navy. I'm not a SEAL. I'm not any of that military stuff either. I have some friends who are and that's about it. When I gave up the profile information the 4 guys decided to be 4 faces and it rolled from there. BLONDGECKO stopped it all and I think I took a bit of time off here. Now I'm back. {/EDIT}

I thought I came across pretty honest but whatever. I'm at the point where this isn't really about me anymore. You guys know who I am.

Shouldn't I be a little frustrated? 150+ posts over a few months and being largely accepted by the norms. Then I add a profile picture and now I'm right back to where I was.

I don't know. Seems like that would get a few people kind of frustrated.

Well anyway... 3 months give or take... yeah a little frustrated.

Geez, man - couldn't you have picked another thread to get caught out in? I liked this one!

For codefrog I cannot view forums at all so posting is definitely out. Wayfarer can do everything but aside from signing in I haven't used it and neither has Dingus.

Everyone knew that. :shrug:

Again. What do you want?

Again. What do you want?

i always wanted a pony

More pictures of naked tits. They don't have to belong to Lucy Lu, but of similar caliber. Thanks a ton.

DMT

Done! PM me your shipping address and it'll arrive next week. I keep my word too. You'll have a pony.

Okay here's the deal. I've got tons of them. Literally millions and millions. But they all are of Polynesian dwarf goat farmers. There's a size limit of 1 meg on photos and we are talking like terabytes. Oh and they are all on floppy's (cheap website all the porn was subscription based on floppy). So I'll keep them here. Someday I'm gong to travel to your end of the country and I'll bring them with me...

My ability with computers is startling. I've been doing covert government work for a very long time, primarily in cyberspace.

. . .

I didn't spend years getting shot at in the world so some of you could continue to take potshots at me here.

. . .

I am completely ready for the mob-war death squads so bring it on. You all remind me of the Republican Guard.

No it was meant to be a "go have fun" type of thing. These are 4 guys I know as well as I know anyone. I'm self-employed and I know my stuff way well.

I was a senior engineer for Micron Technology and wrote their backlog management system for memory modules and wafers. I wrote the Wildlife Management System for Idaho Fish & Game. I wrote the archived license lookup system for Idaho Fish & Game.

When it comes to source code I'm really good. I just got annoyed and on an impulse gave the account away. Then it got worse and worse. I followed it for a bit and then just kind of got really ashamed. So I tried to come back as wayfarer but somebody spotted that in no time flat and I was on the defensive so I gave up.

I registered rockreaver but I didn't post for a very long time (or I think that's right... that was the plan). Then I just tried to be very vanilla. I had real questions I wanted help with and I knew there were good people here. Some of them whom I won't mention have been cool since day one and each time I morphed I told them that I was agent X or Y or Z and they were like "okay".

I have been paid very well to catch hackers. I've programmed CISCO IOS for firewalls. I've done it all and I'm pretty good. I'm pretty burned out on life though keeping a kid alive and the debt has me really fried. All I want to do is climb. That means I hang out here and I read, and read and read and read and read.

Then I add a picture and my whole world goes right to hell. Oh well. You get what you earn and I earned what I'm getting.

I'm starting to lean towards this is just another troll.

Just to harp on this point a bit more (man, I hope I don't derail the promised goat-tit pictures), which was it? 4 guys you know really well, and a "go have fun;" or an "I got annoyed & gave it away?"

Anyway, are the g-t's of similar quality to Lucy's?

No, it has to be a troll because the person behind all of this needs to have the presence of mind to actually do all of that from the beginning.

Nah... I think he's a skilled internet geek, that lacks interpersonal skills, but knows how to live vicariously through created personas like D&D Characters and Trolls - To be an Internet Superhero.

It's the person he wishes he were, but in reality, he's most like the guy who runs the comic book store on The Simpsons:
[image]http://progets.com/simpsons/pics/The%20comic%20book%20guy%20with%20his%20laptop.gif[/image]


He probably really does hate violence, since he was punked and bullied as a kid... Hence the GI Joe fantasy.

Anyway, if you think it took a mental disorder to plan this stuff then you were not paying attention in college but I'll back off on that.

I don't think a troll would spend months and 150+ posts to turn back into a little green dude that pisses people off for fun.

Can we wrap this up? I don't know what you guys are really after now. If you don't like me then ignore my posts. But this is now getting iterative. We are going back to places we've been and in going there it's not really doing much. Have the mods ban me. Wait you are a mod.

...ranting-drama-queen-livejournalesque-walls-of-words that you call "posts."

Somehow, I doubt you have it in you to do this, though.

I've got a normal life to live not a past to be mired in.

Sweet I'm at 180 posts and 180 is a mythic number to me. Farking cool. I'll explain it someday but not here in this thread. 180 is a freaking cool number.

Living vicariously through what? You have to think about this. What vicarious personality am I living right now? If I am it's pretty dull. Wouldn't I have picked something more interesting? I mean I've been asking about trad harnesses, soft shells and slings. That's not much of a vicarious life. Not really at all.

In real life I'm self-employed and I do very well. I know most of the major businessman in this town as well as the CEO of the largest memory maker in America. Just saw him in McCall a few weeks ago and we both talked for about 30 minutes while hanging out on a dock at the waterfront of a lake.

If I'm living vicariously I'm not doing a very good job at all. As far as hating violence mmm not so much. It has it's place and I'll leave it at that. I have good friends in Afghanistan and Iraq as well as other places in the world. Good people and they are... very violent if the situation mandates it. But they are officially "peace keepers" and they like that too. They want to come home to their wives and kids too.

This thread needs a different kind of boob...... come to think of it this whole site is lacking in recent years.

OK back to fapbank.com

... and asking themselves why they didn't think of this first.

Very cool new approach to tackling viruses


There's a long road ahead, and it's not yet certain that it'll work, but holy shit that's a good idea.

Who told you you could post on-topic?

BANZ HIM! Banz him real good!